Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA microRNA. miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
Induction of robust humoral immunity against SARS-CoV-2 after vaccine administration in previously infected haematological cancer patientsArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] SARS, 진단, [키워드] Haematological cancer Humoral immunity induction Patient robust SARS-CoV-2 vaccine administration [DOI] 10.1111/bjh.18429 PMC 바로가기
Induction of Hypoxic Response in Caco-2 Cells Promote the Expression of Genes Involved in SARS-CoV-2 Endocytosis and TranscytosisArticle Published on 2022-10-012022-11-16 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 analyzed Caco-2 Caco-2 cell downregulation elevated endocytosis expression expression level expression of gene hypoxia hypoxic include increase in induction intestine involved LDL LDLR low-density LRP1 LRP4 LRP5 manuscript mechanism miRNA mRNA oxyquinoline receptor response RNA sequencing SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 viral particles significant increase TFRC Transcriptome Transcriptome. transcytosis Transport treated upregulation [DOI] 10.1134/S1607672922050118 PMC 바로가기
Determinants of Neutralizing Antibody Response After SARS CoV-2 Vaccination in Patients With MyelomaArticle Published on 2022-09-102022-11-15 Journal: Journal of clinical oncology : official journal of [Category] SARS, 변종, 진단, 치료기술, [키워드] affected analyzed antibody B-cell malignancy BNT162b2 Booster vaccine Characteristics Critical Delta detect detectable determinant disease environmental exposure Factors greater hosts Immunocompromised implication increased risk induction initial lack Live virus Moderna MONITOR Mortality mRNA1273 much lower Multiple myeloma Myeloma NAb neutralization neutralize neutralizing antibody neutralizing capacity nucleocapsid Patient patients Pseudovirus neutralization assay quantified RBD receiving response SARS CoV-2 Seroconversion Serologic response significantly spike receptor-binding domain the vaccine Treatment vaccination Vaccine vaccine-induced antibody variant viral neutralization virus virus-neutralizing were measured [DOI] 10.1200/JCO.21.02257 PMC 바로가기
Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood전혈에서 중증 급성 호흡기 증후군 코로나바이러스 2-특이적 T 세포 분석을 위한 신속한 사이토카인 방출 분석Article Published on 2022-08-242022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-receptor-binding domain antibody Blood samples characteristic clinical complicate Complication controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine cytokine Cytokine release assay diagnosed Diagnosis Diagnostic accuracy Donor EudraCT evaluated exhibited high accuracy IgG IgG levels Immunoglobulin Immunoglobulin G induction Infection interferon interferon γ memory memory response nucleocapsid Patient peptide peptides plasma Previous studies protocol Rapid receiver receiver operating characteristic Region Release remained respiratory SARS-CoV-2 seropositive serum severe acute respiratory syndrome Coronavirus Spike. stimulated study participant supernatant T cells T-cell T-cell immunity Trial vaccine doses waned Whole blood [DOI] 10.1093/infdis/jiac005 PMC 바로가기 [Article Type] Article
Beta interferons from the extant camelids: Unique among eutherian mammals현존하는 낙타과의 베타 인터페론: eutherian 포유류 중 유일Article Published on 2022-08-012022-09-11 Journal: Developmental and comparative immunology [Category] 유전자 메커니즘, 조류인플루엔자, 치료제, [키워드] Antiviral antiviral response Beta camelid Cell cells coronavirus COVID-19 pandemic cysteine cysteines Cytopathic effect cytopathic effects Defense Dromedary Dromedary camel Endemic event expressed expression Host immune response IFN-β immune mechanism induction Infection interferon interferons invading pathogen invading pathogens kidney mammal mammals MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular offer Outbreaks pandemic pathogen Pathogens poly(I:C) poxvirus Protein recombinant IFN-β respiratory syndrome coronavirus RNA virus Treatment unique virus zoonosis zoonosis. zoonotic zoonotic infections [DOI] 10.1016/j.dci.2022.104443 PMC 바로가기 [Article Type] Article
Induction of Cross-Reacting Antibodies Against the COVID-19 by BCG Vaccination in the Mouse Model마우스 모델에서 BCG 백신 접종에 의한 COVID-19에 대한 교차 반응 항체 유도Article Published on 2022-07-302022-09-11 Journal: Current microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against antibodies antibody Antibody Response approach BCG BCG vaccination boost COVID-19 cross-reacting antibodies demonstrated explain help humoral immune response Immune escape immune responses Immunity induce induction investigated latent tuberculosis latent tuberculosis infection Model mouse mouse model non-specific potential tool potential tools rabies reducing reported SARS-CoV-2 SARS-CoV-2 spike spike tested the antibody response the SARS-CoV-2 Tuberculosis vaccination Vaccines variants [DOI] 10.1007/s00284-022-02971-w PMC 바로가기 [Article Type] Article
Short-Term Effect of SARS-CoV-2 Spike Protein Receptor-Binding Domain-Specific Antibody Induction on Neutrophil-Mediated Immune Response in Mice쥐의 호중구 매개 면역 반응에 대한 SARS-CoV-2 스파이크 단백질 수용체 결합 도메인 특이적 항체 유도의 단기 효과Article Published on 2022-07-262022-09-12 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Activation Affect airway alteration antibodies antibody antibody formation Antibody Response Blood bone marrow cell CD101 Control COVID-19 CXCR2 domain Effect elevate excessive inflammation immunized induction injection Innate immunity investigated mice mimicking mouse model NETs neutrophil Neutrophil extracellular trap neutrophil recruitment Neutrophils Particle phenotype phosphate buffer PROTECT RBD RBD-specific antibodies RBD-specific antibody receptor-binding domain. respiratory inflammation response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus spike stimulate the RBD the spike protein triggering [DOI] 10.3390/ijms23158234 PMC 바로가기 [Article Type] Article
Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle VaccinesS1 나노입자 백신에 의한 SARS-CoV-2 변이체에 대한 광범위한 교차 반응성 항체 반응의 유도Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titers betacoronaviruses Characteristics comparable coronavirus COVID-19 cross-protective immunity cross-reactive cross-reactivity effective elicit elicited exhibited homogeneity humoral immune evasion Immunity induction Infection MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus monomer nanoparticle nanoparticle vaccine Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers novel vaccines omicron pathogenic respiratory respiratory syndrome coronavirus response S1 SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein spike protein S1 stability Vaccine vaccine candidate vaccine candidates Vaccines variant variants variants of concern variants of concern. variants of interest wild-type wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00383-22 PMC 바로가기 [Article Type] Article